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hyaluronidase-3; hyal-3; hyaluronoglucosaminidase-3; lung carcinoma protein 3; LuCa-3 (HYAL3, LUCA3)
Function:
- random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine & D-glucuronate residues in hyaluronate tructure:
- belongs to the glycosyl hydrolase 56 family
- contains 1 EGF-like domain
Compartment: secreted, lysosome
Alternative splicing: named isoforms=5
Expression: expressed in bone marrow, testis, kidney
Pathology:
- isoform 4 is detected in all bladder tumor & prostate tumor cells
General
glycoprotein
hyaluronoglucosaminidase; hyaluronidase (HYAL)
secreted protein
Properties
SIZE: entity length = 417 aa
MW = 47 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-20}
cysteine residue {C42}
MODIFICATION: cysteine residue {C331}
N-glycosylation site {N69}
glutamate residue {E129}
cysteine residue {C205}
MODIFICATION: cysteine residue {C220}
N-glycosylation site {N215}
cysteine residue {C220}
MODIFICATION: cysteine residue {C205}
cysteine residue {C331}
MODIFICATION: cysteine residue {C42}
EGF domain {352-407}
MOTIF: cysteine residue {C356}
MODIFICATION: cysteine residue {C367}
cysteine residue {C361}
MODIFICATION: cysteine residue {C395}
cysteine residue {C367}
MODIFICATION: cysteine residue {C356}
cysteine residue {C395}
MODIFICATION: cysteine residue {C361}
cysteine residue {C397}
MODIFICATION: cysteine residue {C406}
cysteine residue {C406}
MODIFICATION: cysteine residue {C397}
Database Correlations
OMIM 604038
UniProt O43820
Pfam PF01630
Entrez Gene 8372
Kegg hsa:8372
ENZYME 3.2.1.35
References
UniProt :accession O43820