Search
hyaluronidase-2; hyal-2; hyaluronoglucosaminidase-2; lung carcinoma protein 2; LuCa-2 (HYAL2, LUCA2)
Function:
1) hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to yield small oligosaccharides
2) very low levels of activity
3) associates with & negatively regulates MST1R
4) random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine & D-glucuronate residues in hyaluronate
Structure:
- belongs to the glycosyl hydrolase 56 family
- contains 1 EGF-like domain
Compartment: cell membrane, GPI-anchor.
Expression:
- widely expressed
- no expression in adult brain
General
glypiated protein
hyaluronoglucosaminidase; hyaluronidase (HYAL)
secreted protein
Properties
SIZE: entity length = 473 aa
MW = 54 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C47}
MODIFICATION: cysteine residue {C340}
N-glycosylation site {N74}
N-glycosylation site {N103}
glutamate residue {E135}
cysteine residue {C211}
MODIFICATION: cysteine residue {C227}
cysteine residue {C227}
MODIFICATION: cysteine residue {C211}
cysteine residue {C340}
MODIFICATION: cysteine residue {C47}
N-glycosylation site {N357}
EGF domain {361-439}
MOTIF: cysteine residue {C365}
MODIFICATION: cysteine residue {C376}
cysteine residue {C370}
MODIFICATION: cysteine residue {C427}
cysteine residue {C376}
MODIFICATION: cysteine residue {C365}
cysteine residue {C427}
MODIFICATION: cysteine residue {C370}
cysteine residue {C429}
MODIFICATION: cysteine residue {C438}
cysteine residue {C438}
MODIFICATION: cysteine residue {C429}
glycosyl phosphatidylinositol [GPI] membrane anchor {N448}
Database Correlations
OMIM 603551
UniProt Q12891
Pfam PF01630
Entrez Gene 8692
Kegg hsa:8692
ENZYME 3.2.1.35
References
- UniProt :accession Q12891
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/HYAL2ID40904ch3p21.html