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hyaluronate gel for joint injection (Hyalgan, Hylan G-F, Sinvisc-One)

Indications: - osteoarthritis (viscosupplementation) {no benefit [2,4]} {minimal benefit [3]} Contraindications: - 3 injections may provide lubrication to joint but not rapid pain relief Dosage: 1) Hyalgan: 5 intra-articular injections over 4 weeks 2) Hylan G-F: 3 intra-articular injections over 2 weeks Notes: - 15% of patients who undergo total knee arthroplasty receive at least one hyaluronate gel knee injection [5] - mean number of injections/patients = 3.6

Related

hyaluronate; hyaluronic acid; hyaluronan

General

hyaluronate-based injectable gel (Amvisc)

References

  1. Weiner S. In: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  2. Petrella RJ et al Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 162:292, 2002 PMID: 11822921 - Felson DT & Anderson JJ Hyaluronate sodium injections for osteoarthritis: hope, hype, and hard truths. Arch Intern Med 162:245, 2002 PMID: 11822915
  3. Lo GH et al, Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA 290:3115, 2003 PMID: 14679274
  4. Rutjes AWS et al Viscosupplementation for Osteoarthritis of the Knee A Systematic Review and Meta-analysis Annals of Internal Medicine, June 11, 2012 PMID: 22688842 http://www.annals.org/content/early/2012/06/05/0003-4819-157-3-201208070-00473
  5. Weick JW et al. Hyaluronic acid injections for treatment of advanced osteoarthritis of the knee: Utilization and cost in a national population sample. J Bone Joint Surg Am 2016 Sep 7; 98:1429. PMID: 27605686 http://jbjs.org/content/98/17/1429
  6. Department of Veterans Affairs, VA National Formulary