ELAV-like protein 4; paraneoplastic encephalomyelitis antigen HuD; Hu-antigen D (ELAVL4, HUD, PNEM)

Function: - may play a role in neuron-specific RNA processing - protects CDKN1A mRNA from decay by binding to its 3'-UTR - binds to AU-rich sequences (AREs) of target mRNAs, including VEGF & FOS mRNA - methylation at Arg-243 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA & down-regulates CDKN1A protein expression, thus maintaining cells in a proliferative state - methylation is inhibited by NGF, which facilitates neurite outgrowth (putative) - component of a TAU mRNP complex Structure: - belongs to the RRM elav family - contains 3 RRM domain (RNA recognition motif)s Alternative splicing: named isoforms=4 Expression: brain Pathology: - autoantigen in paraneoplastic encephalomyelitis Laboratory: - HuD Ab in serum/plasma

General

antigen RNA-binding protein

Properties

SIZE: entity length = 380 aa MW = 42 kD MOTIF: RNP motif NAME: RNP motif SITE: 46-124 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 132-212 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif RNP motif NAME: RNP motif SITE: 297-375 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif

Database Correlations

OMIM 168360 UniProt P26378 Pfam PF00076 Entrez Gene 1996 Kegg hsa:1996

References

UniProt :accession P26378