HUWE1-associated protein modifying stress responses 2 (HAPSTR2)

Function: - together with HAPSTR1 plays a central regulatory role in the cellular response to molecular stressors, such as DNA damage, nutrient scarcity, & protein misfolding - regulates these multiple stress response signaling pathways by stabilizing HAPSTR1, but also independently of HAPSTR1 - the interaction is direct & stabilizes HAPSTR1 independently of HUWE1 - interacts with HUWE1 (Pubmed:36631436) Structure: - homooligomer, heterooligomer with HAPSTR1 - belongs to the HAPSTR1 family, Compartment: nucleus Expression: -cexpressed in a tissue-restricted manner compared to HAPSTR1

Properties

SIZE: entity length = 273 aa MW = 30 kD COMPARTMENT: cell nucleus

Database Correlations

UniProt A0A7P0TBJ1 Pfam PF15251 Entrez Gene 389895 Kegg hsa:389895

References

UniProt :accession A0A7P0TBJ1