Search
humoral immune dysfunction
Etiology: associated conditions
1) multiple myeloma
2) lymphoma
3) splenectomy
4) complement deficiency - properdin in males
5) Bruton's X-linked agammaglobulinemia
6) agammaglobulinemia
7) chronic lymphocytic leukemia
8) dysglobulinemia
9) selective IgM deficiency
10) selective IgA deficiency
11) common variable immunodieficiency
Pathology: characteristic pathogens (recurrent infections)
1) encapsulated bacteria*
a) Streptococcus pneumonia
b) Staphylococcus aureus
c) Haemophilus influenzae
d) Pseudomonas aeruginosa
e) Neisseria (complement deficiency, late components)
1] N. meningitidis
2] N. gonorrhoeae
2) Mycoplasma
3) Giardia lamblia
4) Escherichia coli
5) enteroviruses
6) hepatitis virus
* recurrent pyogenic infection due to encapsulated organisms for which opsonization or complement mediated lysis is critical
Management:
-> pneumococcal & Haemophilus influenza B vaccine prior to splenectomy
Related
humoral immunity
mixed cellular & humoral immune dysfunction
Specific
complement deficiency
deficient antibody synthesis
hyper-IgM immunodeficiency syndrome (HIGM)
IgG subclass deficiency
selective IgA deficiency
selective IgM deficiency
General
immunodeficiency; immunodeficiency syndrome
References
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998
- Harrison's Principles of Internal Medicine, 13th ed.
Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 497