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human anti-mouse antibody (HAMA)
Etiology:
- administration of mouse monoclonal antibody to human
Epidemiology:
- 1/3 of patients receiving mouse monoclonal antibody
- 10% of population carries some anti-animal antibody
- newer in-vitro techniques manufacture monoclonal antibodies without use of mice, thus new cases becoming a relic of the past
Clinical manifestations:
- variable
- rash
- renal failure
Laboratory:
- diagnostic reagents that use mouse antibodies may not function properly [2]
General
sign/symptom
References
- Wikipedia: Human anti-mouse antibody
http://en.wikipedia.org/wiki/Human_anti-mouse_antibody
- Klee GG.
Human anti-mouse antibodies.
Arch Pathol Lab Med. 2000 Jun;124(6):921-3.
PMID: 10835540