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FK506-binding protein 4 (52 kD FK506 binding protein, hsp-binding immunophilin, FKBP59, FKBP4)
Function:
- component of unactivated mammalian steroid receptor complex together with heat shock proteins HSP70 & HSP90
- may have a rotamase activity
- may play a role in the intracellular trafficking of hetero- oligomeric forms of steroid hormone receptors
- interacts with NR3C1 & dynein (putative)
- associates with HSP90 & HSP70 in unactivated steroid hormone receptor complexes
- interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH)
- phosphorylation by CK2 results in loss of HSP90 binding activity (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
peptidylproline (omega=180) peptidylproline (omega=0)
Structure:
- contains 2 PPIase FKBP-type domains
- contains 3 TPR repeats
Compartment: cytoplasm, nucleus
Expression: widely expressed
General
FK506 binding protein (FKBP)
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 459 aa
MW = 52 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: active site
SITE: 50-138
Thr phosphorylation site {T143}
active site
SITE: 167-253
tetratricopeptide repeat {270-303}
tetratricopeptide repeat {319-352}
tetratricopeptide repeat {353-386}
Ser phosphorylation site {S451}
Ser phosphorylation site {S453}
Database Correlations
OMIM 600611
UniProt Q02790
PFAM correlations
ENZYME 5.2.1.8
References
- Ku Tai et al Science 256:1315 1992
- Martinus RD et al
Role of chaperones in the biogenesis and maintenance of the
mitochondrion.
FASEB J. 1995 Mar;9(5):371-8. Review.
PMID: 7896006
- UniProt :accession Q02790