hook homolog 2 (h-hook2, hHK2, HOOK2)

Function: 1) cytoskeletal linker protein 2) role in tethering membrane bound organelles to cytoskeleton 3) interacts with microtubules Structure: - homodimer - large coiled coil domain probably mediates homodimerization - belongs to the hook family Compartment: - cytoplasm - associates with discrete punctate structure that correspond to neither early or late endosomes, lysosomes, multivesicular bodies (MVBs), Golgi complex, endoplasmic reticulum, nor mitochondria Alternative splicing: named isoforms=2

Properties

SIZE: MW = 83 kD entity length = 719 aa COMPARTMENT: mitochondria cytoplasm golgi endoplasmic reticulum MOTIF: microtuble interaction {1-159} coiled coil {180-661}

Database Correlations

OMIM 607824 UniProt Q96ED9 Pfam PF05622

References

UniProt :accession Q96ED9