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homovanillate in 24 hour urine
Indications:
- evaluation of neuroendocrine tumors
- pheochromocytoma
- neuroblastoma
- ganglioneuroma
Reference interval:
1) adult:
a) 1.4-8.8 mg/day (8-48 umol/day)
b) < 6 ug/mg (< 3.5 mmol/mol) of creatinine*
2) 6-15 years
- < 19 ug/mg (< 12 mmol/mol) of creatinine*
* Creatinine is measured simultaneously to ensure adequate collection of urine & to calculate HVA/creatinine ratio.
Increases:
1) pharmaceutical agents
a) in vivo effects
-> disulfiram, L-dopa/pyridoxine, reserpine
b) chemical interferences (colorimetric methods)
-> aminosalicylic acid
2) clinical disorders
a) pheochromocytoma
b) neuroblastoma
c) ganglioneuroma
Specimen:
1) urine, 24 hours
2) preserve with 20 mL of 6M HCl
3) refrigerate
Methods:
1) HPLC
2) gas chromatography
Related
ganglioneuroma
homovanillate (HVA, homovanillic acid)
neuroblastoma
pheochromocytoma; paroxysmal hypertension; adrenal medullary paraganglioma; chromoffinoma
General
24 hour urine
homovanillate in Urine
References
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995
- RCPA Manual
Royal College of Pathologists of Australia
http://www.rcpamanual.edu.au/index.php?option=com_pttests&task=show_test&id=706&Itemid=34
- Panel of 31 tests
Laboratory Test Directory ARUP: 80422
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