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homeobox protein unc-4 homolog (homeobox protein Uncx4.1, UNCX, UNCX41)
Function:
- transcription factor involved in somitogenesis & neurogenesis
- required for the maintenance & differentiation of particular elements of the axial skeleton
- may act upstream of PAX9
- plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation & to deliver hormones for control of peripheral functions (putative)
Structure:
- belongs to the paired homeobox family, Unc-4 subfamily
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (putative)
General
nuclear protein
Properties
SIZE: entity length = 531 aa
MW = 54 kD
COMPARTMENT: cell nucleus
MOTIF: homeodomain
SITE: 105-164
proline-rich region
SITE: 244-523
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt A6NJT0
Pfam PF00046
Kegg hsa:3402
References
UniProt :accession A6NJT0