homeobox protein TGIF1; 5'-TG-3'-interacting factor 1; TGFB-induced factor (TGIF1 TGIF)

Function: - binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE) - inhibits 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element - active transcriptional corepressor of SMAD2 - links the nodal signaling pathway to the bifurcation of the forebrain & establishment of ventral midline structures - may participate in transmission of nuclear signals during development & in the adult, as suggested by the down-modulation of RXR alpha activities - interacts with CTBP, SMAD2, SMAD3 & HDAC1 Structure: - belongs to the TALE/TGIF homeobox family - contains 1 homeobox DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=2 Pathology: - mutations associated with holoprosencephaly type 4

Properties

SIZE: entity length = 401 aa MW = 43 kD COMPARTMENT: cell nucleus MOTIF: CTBP-binding {153-157} homeodomain SITE: 164-226 MOTIF: arginine-rich region {165-168} MOTIF: arginine residue (SEVERAL)

References

UniProt :accession Q15583

Databases & Figures

OMIM correlations MORBIDMAP 602630 UniProt Q15583 Pfam PF05920 Entrez Gene 7050 Kegg hsa:7050 TGF-beta/BMP signaling