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homeobox protein notochord (NOTO)
Function:
- transcription regulator acting downstream of both FOXA2 & T during notochord development
- required for node morphogenesis
- essential for cilia formation in the posterior notochord & for left-right patterning; acts upstream of FOXJ1 & RFX3 in this process & is required for the expression of various components important for axonemal assembly & function
- role in regulating axial versus paraxial cell fate (putative)
Structure: contains 1 homeobox DNA-binding domain
Compartment: nucleus (putative)
General
nuclear protein
Properties
SIZE: entity length = 251 aa
MW = 27 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 2-68
MOTIF: proline residue (SEVERAL)
homeodomain
SITE: 156-215
Database Correlations
UniProt A8MTQ0
Pfam PF00046
References
UniProt :accession A8MTQ0