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homeobox protein HMX3 (homeobox protein H6 family member 3, homeobox protein Nkx-5.1, HMX3 NKX-51, NKX5-1)
Function:
- transcription factor involved in specification of neuronal cell types
- required for inner ear & hypothalamus development
- binds to the 5'-CAAGTG-3' core sequence
- controls semicircular canal formation in the inner ear
- also required for hypothalamic/pituitary axis of the CNS
Structure:
- belongs to the HMX homeobox family
- contains 1 homeobox DNA-binding domain
Compartment: nucleus (putative)
General
homeobox protein
transcription factor (TF)
Properties
SIZE: entity length = 357 aa
MW = 38 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 2-52
MOTIF: proline residue (SEVERAL)
alanine-rich region {57-84}
MOTIF: alanine residue (SEVERAL)
homeodomain
SITE: 227-286
alanine-rich region {319-326}
MOTIF: alanine residue (SEVERAL)
Database Correlations
UniProt A6NHT5
Pfam PF00046
References
UniProt :accession A6NHT5