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homeobox protein HMX1 (homeobox protein H6, HMX1, H6)
Function:
1) DNA-binding protein
2) binds to the 5'-CAAG-3' core sequence
3) may function as a transcriptional repressor
4) transcriptional antagonist of NKX2-5 (putative)
5) role in the development of craniofacial structures, including eye & ear
Structure:
- belongs to the HMX homeobox family
- contains 1 homeobox DNA-binding domain
Compartment: nucleus
General
DNA-binding protein
homeobox protein
Properties
SIZE: MW = 39 kD
entity length = 373 aa
COMPARTMENT: cell nucleus
MOTIF: arginine-rich region {34-68}
MOTIF: arginine residue (SEVERAL)
homeodomain
SITE: 200-259
HMX family specific domain 1 {260-270}
proline-rich region
SITE: 287-353
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 142992
UniProt Q9NP08
Pfam PF00046
References
UniProt :accession Q9NP08