homeobox protein cut-like 2; homeobox protein cux-2 (CUX2, CUTL2, KIAA0293)

Function: - may be a transcription factor involved in neural specification - binds to DNA in a sequence-specific manner Structure: - belongs to the CUT homeobox family - contains 3 CUT DNA-binding domains - contains 1 homeobox DNA-binding domain Compartment: nucleus (putative)

General

DNA-binding protein homeobox protein phosphoprotein

Properties

SIZE: entity length = 1486 aa MW = 162 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S143} Thr phosphorylation site {T159} Ser phosphorylation site {S162} coiled coil {195-374} proline-rich region SITE: 440-535 MOTIF: proline residue (SEVERAL) DNA-binding motif SITE: 544-631 coiled coil {690-717} serine-rich region {802-813} MOTIF: serine residue (SEVERAL) DNA-binding motif SITE: 887-974 DNA-binding motif SITE: 1038-1125 homeodomain SITE: 1168-1227 proline-rich region SITE: 1327-1437 MOTIF: proline residue (SEVERAL)

Database Correlations

OMIM 610648 UniProt O14529 PFAM correlations Entrez Gene 23316 Kegg hsa:23316

References

UniProt :accession O14529