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high molecular weight [HMW] kininogen; alpha-2 thiol proteinase inhibitor (KNG1)
Normally exists in plasma in a 1:1 complex with prekallikrein. HMW kininogen supports reciprocal activation of factor XII, factor XI & prekallikrein.
Interactions
molecular events
Related
coagulation cascade
General
coagulation factor
kininogen
multisubunit protein
Properties
SIZE: MW = 110-150 kD
COMPARTMENT: plasma
INHIBITS: cysteine proteinase
MOTIF: cysteine-rich region {N-TERMINAL} (3)
FOR-BINDING-OF: cysteine proteinase
proteolytic site
glycosylation site
WKS motif
PRECURSOR-FOR: bradykinin
Database Correlations
OMIM 228960
UniProt P01042
Kegg hsa/hsaKEGG
References
- Andrews BS.
Is the WKS motif the tissue-factor binding site for coagulation
factor VII?
Trends Biochem Sci. 1991 Jan;16(1):31-6. Review.
PMID: 2053135
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
Component-of
macromolecular complex