HMG box-containing protein 1 (HMG box transcription factor 1, high mobility group box transcription factor 1, HBP1)

Function: 1) transcriptional repressor 2) binds to the promoter region of target genes 3) regulation of the cell cycle 4) regulation of Wnt pathway 5) binds preferentially to 5'-TTCATTCATTCA-3 6) binding to the H1F0 promoter is enhanced by interaction with RB1 7) disrupts the interaction between DNA & TCF4 8) binds the 2nd PAH repeat of SIN3A 9) binds TCF4 & RB Compartment: nucleus Alternative splicing: named isoforms=3

General

HMG box transcription factor transcriptional silencer (transcriptional repressor)

Properties

SIZE: MW = 58 kD entity length = 514 aa COMPARTMENT: cell nucleus MOTIF: serine-rich region {156-161} MOTIF: serine residue (SEVERAL) AXH {203-345} HMG box SITE: 434-502

Database Correlations

UniProt O60381 PFAM correlations

References

UniProt :accession O60381