HIV Tat-specific factor 1 (HTATSF1, Tat-SF1)

Function: 1) general transcription factor a) transcriptional elongation b) stimulatory effect of splicing on transcriptional elongation 2) component of Tat-SF complex 3) interacts with TCERG1/CA150, snRNPs Compartment: nucleus Expression: widely expressed Pathology: 1) up-regulated by the HIV-1 proteins NEF & gp120 2) acts as a cofactor required for Tat-enhanced transcription of HIV1

General

general transcription factor (basal transcription factor, transcription initiation factor) phosphoprotein

Properties

SIZE: MW = 86 kD entity length = 755 aa COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 133-218 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif lysine-rich region {228-234} MOTIF: lysine residue (SEVERAL) RNP motif NAME: RNP motif SITE: 264-349 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Mediates interaction with the P-TEFb complex. {381-755} MOTIF: acidic region {423-754} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S624} Ser phosphorylation site {S642} Ser phosphorylation site {S702}

Database Correlations

OMIM 300346 UniProt O43719 Pfam PF00076

References

UniProt :accession O43719