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HIV1 vaccine

Notes: - no successful vaccine - HVTN 505 clinical trial of an investigational HIV vaccine halted April 2103 because the vaccine did not prevent HIV infection or reduce HIV viral load in those that became infected ith HIV1 [1] - DNA/rAd5 HIV-1 preventive vaccine ineffective in high-risk population [2] - active immunization against HIV1 has not been successful - in monkeys, a single injection of multiple broadly neutralizing antibodies provides protection for many weeks against acquiring HIV1 [3]

Related

human immunodeficiency virus-1 (HIV-1)

General

vaccine

References

  1. NIH News. April 25, 2013 NIH Discontinues Immunizations in HIV Vaccine Study
  2. Hammer SM et al. Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. N Engl J Med 2013 Oct 7 PMID: 24099601 http://www.nejm.org/doi/full/10.1056/NEJMoa1310566
  3. autam R, Nishimura Y, Pegu A A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges. Nature. 2016 May 5;533(7601):105-9. Epub 2016 Apr 27. PMID: 27120156