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HIV1 enhancer-binding protein 2; transcription factor HIVEP2; HIV-EP2; MHC-binding protein 2; MBP-2 (HIVEP2)
Function:
- specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1
- related sequences are found in the enhancer elements of a number of cellular promoters, including those of MHC class 1, IL2 receptor, somatostatin receptor 2, & interferon-beta genes
- may have role in T-cell activation
- interacts with TCF4 (putative)
Structure: contains 4 C2H2-type Zn+2 fingers
Compartment: nucleus
Expression:
- expressed in brain & skeletal muscle
- induced by mitogens & phorbol ester
General
C2H2 type zinc finger protein
DNA-binding protein
phosphoprotein
transcription factor (TF)
Properties
SIZE: entity length = 2446 aa
MW = 269 kD
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 189-211
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 217-239
EFFECTOR-BOUND: Zn+2
nuclear translocation signal {937-943}
serine-rich region {950-982}
MOTIF: serine residue (SEVERAL)
serine-rich region {1510-1586}
MOTIF: serine residue (SEVERAL)
Zn finger C2H2-type
SITE: 1799-1821
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1827-1851
EFFECTOR-BOUND: Zn+2
acidic region {1899-1923}
MOTIF: acidic residue (SEVERAL)
tandem repeats {2053-2148}
MOTIF: consensus repeat {2053-2056}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2059-2062}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2071-2074}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
Ser phosphorylation site {S2071}
arginine-rich region {2073-2148}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S2077}
consensus repeat {2083-2086}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2089-2092}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2106-2109}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2112-2115}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2118-2121}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2130-2133}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
consensus repeat {2145-2148}
SEQUENCE-IS: S-P-[RGMKC]- [RK]
Database Correlations
OMIM 143054
UniProt P31629
Pfam PF00096
Kegg hsa:3097
References
UniProt :accession P31629