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HIV1/hepatitis C-coinfection

Laboratory: - normal serum ALT not associated with less extensive hepatic fibrosis (in contrast to patients with only HCV) [1] Complications: - increased risk for progression of hepatitis B & hepatitis C in patients with HIV1 infection - increased risk for non-Hodgkin's lymphoma [3] Management: 1) referral to GI for biopsy 2) referral for HCV treatment 3) lamivudine protective against liver-related deaths [2]

General

coinfection; superinfection hepatitis C infection complications in patients with HIV1 infection

References

  1. Gonzalez SA et al, HIV/hepatitis C virus - coinfected patients with normal alanine aminotransferase levels. J Acquired Immune Defic Syndr 2006; 41:582 PMID: 166722894
  2. Puoti M et al, Impact of lamivudine on the risk of liver-related death in 1,041 HBsAg- and HIV-positive individuals. Results from an inter-cohort analysis. Antir Ther 2006, 11:567 PMID: 16964824
  3. Wang Q, De Luca A, Smith C et al Chronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected Patients: A Cohort Study. Annals of Internal Medicine. Oct 18, 2016 PMID: 27750294 http://annals.org/aim/article/2569661/chronic-hepatitis-b-c-virus-infection-risk-non-hodgkin-lymphoma
  4. Coinfection with HIV and Viral Hepatitis http://www.cdc.gov/hepatitis/hiv-hepatitis-coinfection.htm