histone-lysine N-methyltransferase SETD2 (SET domain-containing protein 2, hSET2, Huntingtin-interacting protein HYPB, Huntingtin yeast partner B, Huntingtin-interacting protein 1, HIF-1, p231HBP, SETD2, HIF1, HYPB, KIAA1732, SET2, HSPC069)

Function: 1) histone methyltransferase 2) methylates Lys-36 of histone H3. 3) histone H3 Lys-36 methylation represents a specific tag for epigenetic transcriptional activation 4) role in chromatin structure modulation during elongation via interaction with hyperphosphorylated POLR2A (putative) 5) binds DNA at promoters 6) transcription activator that binds to promoters 7) interacts with hyperphosphorylated C-terminal domain (CTD) of RNA polymerase 2 large subunit (POLR2A) 8) binds specifically to CTD heptad repeats doubly phosphorylated on Ser-2 & Ser-5 of each heptad 9) interacts with HD 10) low charge region mediates transcriptional activation 11) automethylated (putative) S-adenosyl-L-methionine + histone L-lysine S-adenosyl-L-homocysteine + histone 6-N-methyl-L-lysine Structure: 1) belongs to the histone-lysine methyltransferase family, SET2 subfamily 2) contains 1 AWS domain - contains 1 post-SET domain - contains 1 SET domain - contains 1 WW domain Compartment: nucleus Alternative splicing: named isoforms=3 Expression: ubiquitously expressed Pathology: - binds to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression

Related

huntingtin-interacting protein 1; HIP-1 (HIP1) Huntington's disease [HD] protein (huntingtin) or IT15 protein

General

histone N-methyltransferase phosphoprotein SET domain-containing protein

Properties

SIZE: MW = 288 kD entity length = 2564 aa COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 166-247 MOTIF: proline residue (SEVERAL) arginine-rich region {385-456} MOTIF: arginine residue (SEVERAL) Ser phosphorylation site {S1413} AWS {1494-1548} SET domain {1549-1671} post-SET domain {1674-1690} coiled coil {2117-2146} Low charge region {2137-2366} MOTIF: proline-rich region SITE: 2149-2232 MOTIF: proline residue (SEVERAL) glutamine-rich region {2266-2365} MOTIF: glutamine residue (SEVERAL) WW domain (W/rsp5/WWP domain) {2389-2422} binding site SITE: 2457-2564 FOR-BINDING-OF: RNA polymerase-2 L'

Database Correlations

UniProt Q9BYW2 ENZYME 2.1.1.43

References

UniProt :accession Q9BYW2