Histone-lysine N-methyltransferase SETD1B (SET domain-containing protein 1B, hSET1B, lysine N-methyltransferase 2G, SETD1B, KIAA1076, KMT2G, SET1B)

Function: - histone methyltransferase that specifically methylates Lys-4 of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring Lys-9 is already methylated - histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation - non-overalpping localization with SETD1A suggests that SETD1A & SETD1B make non-redundant contributions to the epigenetic control of chromatin structure & gene expression - specifically tri-methylates Lys-4 of histone H3 in vitro - interacts with HCFC1 - component of the SET1 complex S-adenosyl-L-methionine + histone L-lysine S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine Structure: - contains 1 post-SET domain - contains 1 RRM (RNA recognition motif) domain - contains 1 SET domain Compartment: - nuclear speckle - localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A & SET1B each bind to a unique set of target genes

General

histone N-methyltransferase phosphoprotein SET domain-containing protein

Properties

SIZE: entity length = 1923 aa MW = 209 kD COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 93-181 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif proline-rich region SITE: 366-1628 MOTIF: proline residue (SEVERAL) glutamate-rich region {989-1269} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S1616} Ser phosphorylation site {S1620} SET domain {1783-1905} post-SET domain {1907-1923}

Database Correlations

UniProt Q9UPS6 Pfam PF00856 ENZYME 2.1.1.43

References

UniProt :accession Q9UPS6