histone-lysine N-methyltransferase ASH1L (ASH1-like protein, absent small & homeotic disks protein 1 homolog, huASH1, ASH1L, KIAA1420)

Function: 1) histone methyltransferase 2) methylates Lys-4 of histone H3 (putative), a specific tag for epigenetic transcriptional activation S-adenosyl-L-methionine + histone L-lysine S-adenosyl-L-homocysteine + histone 6-N-methyl-L-lysine Structure: - belongs to the histone-lysine methyltransferase family, SET2 subfamily - contains 3 A.T hook DNA-binding domains - contains 1 AWS domain - contains 1 BAH domain - contains 1 bromo domain - contains 1 PHD-type zinc finger - contains 1 post-SET domain - contains 1 SET domain Compartment: - nucleus, cell junction, tight junction - relevance of tight junction localization unclear Expression: - widely expressed - highest level in brain, heart, kidney

General

histone N-methyltransferase zinc finger protein

Properties

SIZE: MW = 333 kD entity length = 2969 aa COMPARTMENT: cell nucleus MOTIF: A+T hook SITE: 887-899 A+T hook SITE: 1347-1359 proline-rich region SITE: 1380-1424 MOTIF: proline residue (SEVERAL) serine-rich region {1580-1791} MOTIF: serine residue (SEVERAL) A+T hook SITE: 1847-1859 AWS {2091-2142} SET domain {2144-2265} post-SET domain {2269-2285} bromodomain {2463-2533} Zn finger PHD-type NAME: Zn finger PHD-type SITE: 2585-2631 EFFECTOR-BOUND: Zn+2 BAH {2661-2798}

Database Correlations

OMIM 607999 UniProt Q9NR48 ENZYME 2.1.1.43

References

UniProt :accession Q9NR48