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histone H3-specific methyltransferase complex
Function:
- histone H3-specific methyltransferase activity
Structure:
- subunits include: ASCL2, C11orf30/EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 & ZNF335
General
molecular complex
Properties
SUBUNITS: Achaete-scute homolog 2
COMPARTMENT: cell nucleus
MOTIF: arginine-rich region {36-39}
MOTIF: arginine residue (SEVERAL)
DNA-binding motif
SITE: 53-63
helix-loop-helix
NAME: helix-loop-helix
SITE: 64-103
FOR-BINDING-VIA: helix-loop-helix
protein EMSY
COMPARTMENT: cell nucleus
MOTIF: interaction with BRCA2 {1-478}
MOTIF: ENT {16-100}
interaction with ZMYND11 {104-108}
serine-rich region {209-213}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S209}
Ser glycosylation site {S228}
Ser phosphorylation site {S238}
serine-rich region {326-391}
MOTIF: serine residue (SEVERAL)
glutamine-rich region {395-464}
MOTIF: glutamine residue (SEVERAL)
threonine-rich region {496-636}
MOTIF: threonine residue (SEVERAL)
serine-rich region {719-723}
MOTIF: serine residue (SEVERAL)
glutamine-rich region {945-1099}
MOTIF: glutamine residue (SEVERAL)
Ser phosphorylation site {S1136}
host cell factor
COMPARTMENT: cell nucleus
MOTIF: kelch repeat {44-313} (5)
binding site
SITE: 610-722
FOR-BINDING-OF: paired amphipathic helix protein sin3a
binding site
SITE: 750-902
FOR-BINDING-OF: zinc finger & BTB domain-containing protein 17
binding site
SITE: 813-912
FOR-BINDING-OF: GABP2
HCF {1010-1035}
MOTIF: proteolytic site {1019-1020}
HCF {1072-1097}
MOTIF: proteolytic site {1081-1082}
HCF {1101-1126}
MOTIF: proteolytic site {1110-1111}
HCF {1158-1183}
HCF {1286-1311}
MOTIF: proteolytic site {1295-1296}
HCF {1314-1339}
MOTIF: proteolytic site {1323-1324}
HCF {1349-1374}
HCF {1414-1439}
MOTIF: proteolytic site {1423-1424}
heat shock cognate 71 kD protein
COMPARTMENT: cytoplasm
MOTIF: Tyr phosphorylation site {Y15}
Ser phosphorylation site {S153}
Thr phosphorylation site {T477}
cell cycle & apoptosis regulator protein 2
COMPARTMENT: cell nucleus
MOTIF: Thr phosphorylation site {T35}
Ser phosphorylation site {S124}
Ser phosphorylation site {S675}
Ser phosphorylation site {S678}
Ser phosphorylation site {S681}
coiled coil {829-909}
matrin-3
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Ser phosphorylation site {S22}
Ser phosphorylation site {S118}
Ser phosphorylation site {S188}
Ser phosphorylation site {S195}
Ser phosphorylation site {S206}
Ser phosphorylation site {S208}
Ser phosphorylation site {S397}
RNP motif
NAME: RNP motif
SITE: 398-473
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
RNP motif
NAME: RNP motif
SITE: 496-571
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
NAME: ribonucleoprotein-1 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
ribonucleoprotein-2 motif
FOR-BINDING-OF: ribonucleic acid
MOTIF: ribonucleoprotein-1 motif
ribonucleoprotein-2 motif
Ser phosphorylation site {S533}
Ser phosphorylation site {S596}
Ser phosphorylation site {S598}
Ser phosphorylation site {S604}
Ser phosphorylation site {S606}
Ser phosphorylation site {S654}
Ser phosphorylation site {S671}
Ser phosphorylation site {S673}
Ser phosphorylation site {S674}
Ser phosphorylation site {S696}
nuclear translocation signal {710-718}
Tyr phosphorylation site {Y773}
Zn finger matrin-type
NAME: Zn finger matrin-type
SITE: 801-832
EFFECTOR-BOUND: Zn+2
antigen KI-67
COMPARTMENT: cell nucleus
MOTIF: forkhead-associated (FHA) domain {27-76}
Ser phosphorylation site {S108}
Thr phosphorylation site {T109}
Ser phosphorylation site {S125}
Ser phosphorylation site {S128}
Ser phosphorylation site {S131}
Ser phosphorylation site {S264}
Ser phosphorylation site {S308}
Thr phosphorylation site {T328}
Thr phosphorylation site {T347}
Ser phosphorylation site {S352}
Ser phosphorylation site {S357}
Ser phosphorylation site {S374}
Thr phosphorylation site {T401}
Ser phosphorylation site {S411}
Ser phosphorylation site {S538}
Thr phosphorylation site {T543}
Ser phosphorylation site {S579}
Ser phosphorylation site {S584}
Ser phosphorylation site {S630}
Ser phosphorylation site {S648}
Ser phosphorylation site {S713}
Thr phosphorylation site {T761}
Ser phosphorylation site {S827}
Ser phosphorylation site {S859}
consensus repeat {1000-1112}
MOTIF: Thr phosphorylation site {T1017}
Ser phosphorylation site {S1098}
Thr phosphorylation site {T1111}
consensus repeat {1122-1234}
MOTIF: Ser phosphorylation site {S1131}
Thr phosphorylation site {T1139}
Thr phosphorylation site {T1176}
Thr phosphorylation site {T1193}
Ser phosphorylation site {S1207}
Thr phosphorylation site {T1233}
Thr phosphorylation site {T1237}
consensus repeat {1244-1356}
MOTIF: Ser phosphorylation site {S1253}
Ser phosphorylation site {S1256}
Thr phosphorylation site {T1261}
Thr phosphorylation site {T1298}
Ser phosphorylation site {S1302}
Thr phosphorylation site {T1315}
Thr phosphorylation site {T1327}
Ser phosphorylation site {S1329}
Thr phosphorylation site {T1335}
Thr phosphorylation site {T1355}
consensus repeat {1366-1477}
MOTIF: Ser phosphorylation site {S1375}
Ser phosphorylation site {S1376}
Thr phosphorylation site {T1383}
consensus repeat {1487-1598}
MOTIF: Thr phosphorylation site {T1503}
Ser phosphorylation site {S1506}
Thr phosphorylation site {T1540}
Ser phosphorylation site {S1546}
Tyr phosphorylation site {Y1552}
Thr phosphorylation site {T1557}
Thr phosphorylation site {T1565}
Thr phosphorylation site {T1569}
Ser phosphorylation site {S1571}
consensus repeat {1608-1720}
MOTIF: Ser phosphorylation site {S1618}
Ser phosphorylation site {S1628}
Ser phosphorylation site {S1629}
Ser phosphorylation site {S1636}
Ser phosphorylation site {S1679}
Ser phosphorylation site {S1689}
Thr phosphorylation site {T1719}
Ser phosphorylation site {S1721}
Ser phosphorylation site {S1726}
consensus repeat {1730-1842}
MOTIF: Ser phosphorylation site {S1740}
Thr phosphorylation site {T1747}
Thr phosphorylation site {T1764}
Thr phosphorylation site {T1784}
Thr phosphorylation site {T1801}
Ser phosphorylation site {S1815}
Thr phosphorylation site {T1841}
consensus repeat {1851-1964}
MOTIF: Ser phosphorylation site {S1861}
Ser phosphorylation site {S1864}
Thr phosphorylation site {T1869}
Thr phosphorylation site {T1897}
Thr phosphorylation site {T1923}
Ser phosphorylation site {S1937}
consensus repeat {1974-2086}
MOTIF: Ser phosphorylation site {S1983}
Ser phosphorylation site {S2002}
Thr phosphorylation site {T2065}
Ser phosphorylation site {S2072}
Thr phosphorylation site {T2085}
consensus repeat {2096-2204}
MOTIF: Ser phosphorylation site {S2105}
Thr phosphorylation site {T2113}
Ser phosphorylation site {S2135}
Thr phosphorylation site {T2203}
Thr phosphorylation site {T2211}
consensus repeat {2214-2326}
MOTIF: Ser phosphorylation site {S2223}
Thr phosphorylation site {T2231}
Ser phosphorylation site {S2239}
Thr phosphorylation site {T2285}
Ser phosphorylation site {S2299}
Thr phosphorylation site {T2305}
Thr phosphorylation site {T2325}
Thr phosphorylation site {T2328}
Thr phosphorylation site {T2332}
consensus repeat {2335-2447}
MOTIF: Ser phosphorylation site {S2344}
Thr phosphorylation site {T2352}
Ser phosphorylation site {S2355}
Thr phosphorylation site {T2389}
Ser phosphorylation site {S2395}
Thr phosphorylation site {T2406}
Ser phosphorylation site {S2420}
Thr phosphorylation site {T2426}
Thr phosphorylation site {T2446}
consensus repeat {2457-2569}
MOTIF: Ser phosphorylation site {S2466}
Ser phosphorylation site {S2471}
Ser phosphorylation site {S2505}
Thr phosphorylation site {T2508}
Thr phosphorylation site {T2509}
Ser phosphorylation site {S2528}
consensus repeat {2579-2689}
MOTIF: Ser phosphorylation site {S2588}
Ser phosphorylation site {S2638}
consensus repeat {2699-2808}
MOTIF: Ser phosphorylation site {S2708}
consensus repeat {2818-2928}
MOTIF: Ser phosphorylation site {S2827}
Ser phosphorylation site {S2828}
ATP-binding site
NAME: ATP-binding site
SITE: 3034-3041
MOTIF: Ser phosphorylation site {S3041}
Ser phosphorylation site {S3042}
Ser phosphorylation site {S3082}
Ser phosphorylation site {S3207}
Thr phosphorylation site {T3213}
Ser phosphorylation site {S3216}
Thr phosphorylation site {T3223}
retinoblastoma binding protein 5
COMPARTMENT: cell nucleus
MOTIF: WD repeat {22-63}
WD repeat {64-103}
WD repeat {148-188}
MOTIF: Ser phosphorylation site {S182}
Thr phosphorylation site {T193}
WD repeat {196-235}
WD repeat {249-291}
MOTIF: Thr phosphorylation site {T252}
WD repeat {293-331}
Ser phosphorylation site {S350}
Ser phosphorylation site {S388}
Ser phosphorylation site {S389}
Ser phosphorylation site {S497}
tubulin beta-2A chain
MOTIF: GTP-binding site
SITE: 140-146
WD repeat-containing protein 5
COMPARTMENT: cell nucleus
MOTIF: WD repeat {43-82}
WD repeat {85-126}
MOTIF: aspartate residue {107}
WD repeat {128-168}
MOTIF: phenylalanine residue {133}
WD repeat {169-208}
WD repeat {212-253}
WD repeat {256-296}
MOTIF: phenylalanine residue {263}
Ser phosphorylation site {S267}
WD repeat {299-333}
MOTIF: glutamate residue {322}
zinc finger protein 335
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 245-268
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S416}
Zn finger C2H2-type
SITE: 465-487
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 495-517
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 523-545
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 562-584
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 590-612
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 621-643
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 649-672
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 678-701
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S976}
Zn finger C2H2-type
SITE: 1019-1041
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1047-1069
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1075-1097
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 1103-1126
EFFECTOR-BOUND: Zn+2
Ser phosphorylation site {S1153}
glutamine-rich region {1178-1330}
MOTIF: glutamine residue (SEVERAL)
References
UniProt :accession Q8N163
Components
Achaete-scute homolog 2; ASH-2; hASH2; mash2; class A basic helix-loop-helix protein 45; bHLHa45 (ASCL2, BHLHA45 HASH2)
antigen KI-67 (MKI67)
cell cycle & apoptosis regulator protein 2; cell division cycle & apoptosis regulator protein 2; DBIRD complex subunit KIAA1967; deleted in breast cancer gene 1 protein; DBC-1; DBC.1; p30 DBC (CCAR2, DBC1, KIAA1967)
heat shock cognate 71 kD protein (heat shock 70 kD protein 8, HSPA8, HSC70, HSP73, HSPA10)
host cell factor; HCF; HCF-1; C1 factor; VP16 accessory protein; VCAF; CFF (HCFC1, HCF1)
matrin-3 (MATR3, KIAA0723 matrin)
protein EMSY (EMSY, C11orf30, GL002)
retinoblastoma-binding protein 5; RBBP-5; retinoblastoma-binding protein RBQ-3 (RBBP5, RBQ3)
tubulin beta-2A chain (TUBB2A TUBB2)
WD repeat-containing protein 5; BMP2-induced 3-kb gene protein (WDR5, BIG3)
zinc finger protein 335; NRC-interacting factor 1; NIF-1 (ZNF335)