histone H2A-like 3; H2A.L.3 (H2AL3, H2AL1RP)

Function: - core component of nucleosome - nucleosomes wrap & compact DNA into chromatin, limiting DNA accessibility to cellular machinery which requires DNA as a template - histones thus play a central role in transcription regulation, DNA repair, DNA replication & chromosomal stability - DNA accessibility is regulated via a complex set of post-translational modifications of histones (histone code), & nucleosome remodeling - the nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 & H4 assembled in one H3-H4 heterotetramer & two H2A-H2B heterodimers - the octamer wraps approximately 147 bp of DNA Structure: belongs to the histone H2A family, Compartment: nucleus . chromosome

Properties

SIZE: entity length = 148 aa MW = 18 kD COMPARTMENT: cell nucleus

References

UniProt :accession A0A3B3IU63