histone deacetylase complex subunit SAP130 (130 kD Sin3-associated polypeptide, Sin3-associated polypeptide p130, SAP130)

Function: - transcriptional repressor - may function in the assembly &/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex & other regulatory complexes - component of a mSin3A corepressor complex - acetylated (probable) Structure: - belongs to the SAP130 family - N-terminus may interact with a transcriptional coactivator - C-terminus may interact with HDAC-dependent & HDAC- independent corepressors Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: expressed in various cancer cell ines

Properties

SIZE: MW = 110 kD entity length = 1048 aa COMPARTMENT: cell nucleus MOTIF: serine-rich region {81-85} MOTIF: serine residue (SEVERAL) proline-rich region SITE: 124-169 MOTIF: proline residue (SEVERAL) alanine-rich region {234-238} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 709-836 MOTIF: proline residue (SEVERAL) SIN3A & HDAC1 interactions {836-1047}

References

UniProt :accession Q9H0E3