Histone-arginine methyltransferase CARM1; protein arginine N-methyltransferase 4; coactivator-associated arginine methyltransferase 1 (CARM1, PRMT4)

Function: 1) methylates guanidino nitrogens of Arg in a) histone H3 b) EP300/P300 c) PABP1 2) regulation of gene expression 3) chromatin remodeling 4) regulation of skeletal muscle differentiaton 5) inhibits CREB-dependent transcription 6) p53/TP53 transcriptional activation Compartment: nucleus, cytoplasm Alternative splicing: Pathology: - overexpressed in prostate adenocarcinomas & high-grade prostatic intraepithelial neoplasia.

General

nuclear protein N-methyltransferase

Properties

SIZE: entity length = 608 aa MW = 66 kD COMPARTMENT: cytoplasm nuclear membrane MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl binding site SITE: 159-159 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 168-168 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 192-192 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 214-214 FOR-BINDING-OF: S-adenosylmethionine Ser phosphorylation site {S216} binding site SITE: 243-243 FOR-BINDING-OF: S-adenosylmethionine binding site SITE: 271-271 FOR-BINDING-OF: S-adenosylmethionine active site transcriptional activation domain SITE: 499-608

Database Correlations

OMIM 603934 UniProt Q86X55 PFAM correlations Entrez Gene 10498 Kegg hsa:10498 ENZYME 2.1.1.125

References

UniProt :accession Q86X55