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histone acetyltransferase type B catalytic subunit (HAT1)
Function:
- may play a role in telomeric silencing
- acetylates soluble but not nucleosomal H4 at Lys-5 & Lys-12
- acetylates histone H2A at Lys-5
- HAT1 has intrinsic substrate specificity that modifies Lys in recognition sequence GXGKXG
- heteromer of HAT1 & p46/HAT2 subunits
acetyl-CoA + histone CoA + acetylhistone
Structure: belongs to the HAT1 family
Compartment:
- nucleus; nuclear in S-phase
- cytoplasm
General
acyltransferase
nuclear protein
Properties
SIZE: entity length = 419 aa
MW = 50 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S361}
Database Correlations
OMIM 603053
UniProt O14929
Entrez Gene 8520
ENZYME 2.3.1.48
References
- UniProt :accession O14929
- Wikipedia; histone acetyltransferase entry
http://en.wikipedia.org/wiki/histone_acetyltransferase
Component-of
histone acetyltransferase complex type B