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histone acetyltransferase complex type B
Function:
- acetylation of histones
- may play a role in telomeric silencing
- acetylates soluble but not nucleosomal H4 at Lys-5 & Lys-12
- acetylates histone H2A at Lys-5
- required for chromatin assembly following DNA replication
Structure:
- subunits: HAT1, RBBP7 (HAT2)
General
histone acetyltransferase complex
Properties
SUBUNITS: histone acetyltransferase type B catalytic subunit
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S361}
histone-binding protein RBBP7
COMPARTMENT: cell nucleus
MOTIF: WD repeat {121-152}
WD repeat {174-205}
WD repeat {224-255}
WD repeat {270-301}
WD repeat {314-345}
Ser phosphorylation site {S354}
WD repeat {371-402}
Ser phosphorylation site {S413}
Thr phosphorylation site {T416}
References
UniProt :accession O75081
Components
histone acetyltransferase type B catalytic subunit (HAT1)
histone-binding protein RBBP7; retinoblastoma-binding protein 7; RBBP-7; retinoblastoma-binding protein p46; histone acetyltransferase type B subunit 2; nucleosome-remodeling factor subunit RBAP46 (RBBP7, RBAP46, HAT2)