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histone acetyltransferase KAT7; histone acetyltransferase binding to ORC1; lysine acetyltransferase 7; MOZ, YBF2/SAS3, SAS2 & TIP60 protein 2; MYST-2 (KAT7, HBO1, HBOa, MYST2)
Function:
1) histone acetyltransferase
2) specifically represses AR-mediated transcription
3) DNA replication (putative)
4) interacts with MCM2, ORC1L, androgen receptor in presence of dihydrotestosterone
5) component of the HBO1 complex
6) phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- the C2HC-type Zn+2 finger is required for interaction with MCM2 & ORC1L
- the N-terminus is involved in transcriptional repression,
- the C-terminus mediates AR-interaction (putative)
- belongs to the MYST (SAS/MOZ) family
- contains 1 C2HC-type Zn+2 finger
Compartment: nucleus
Expression:
- ubiquitously expressed
- highest levels in testis
General
histone acetyltransferase
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 611 aa
MW = 71 kD
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {10-57}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S50}
Ser phosphorylation site {S52}
Ser phosphorylation site {S53}
Ser phosphorylation site {S56}
Ser phosphorylation site {S57}
Thr phosphorylation site {T85}
Thr phosphorylation site {T88}
Ser phosphorylation site {S99}
Ser phosphorylation site {S100}
Ser phosphorylation site {S102}
Thr phosphorylation site {T104}
Ser phosphorylation site {S124}
Thr phosphorylation site {T128}
Zn finger C2HC-type
SITE: 366-388
EFFECTOR-BOUND: Zn+2
cysteine residue {C474}
binding site
SITE: 477-477
FOR-BINDING-OF: Acetyl-CoA
Acetyl-CoA binding {482-488}
binding site
SITE: 512-512
FOR-BINDING-OF: Acetyl-CoA
Database Correlations
OMIM 609880
UniProt O95251
PFAM correlations
Entrez Gene 11143
KEGG correlations
ENZYME 2.3.1.48
References
UniProt :accession O95251
Component-of
HBO1 complex