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histone acetyltransferase KAT5; 60 kD Tat-interactive protein; Tip60; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein; lysine acetyltransferase 5; cPLA(2)-interacting protein (KAT5, HTATIP, TIP60)
Function:
- catalytic subunit of the NuA4 histone acetyltransferase complex
- directly acetylates & activates ATM
- in case of HIV1 infection, interaction with HIV1 Tat protein leads to KAT5 polyubiquitination & targets it to degradation
- sumoylated by UBE2I at Lys-430 & Lys-451, leading to increase of its histone acetyltransferase activity in UV-induced DNA damage response, as well as its translocation to nuclear bodies
- phosphorylated on Ser-86 & Ser-90; enhanced during G2/Mphase
- phosphorylated form has a higher activity
- ubiquitinated by MDM2, leading to its proteasome-dependent degradation
- autoacetylation at Lys-327 is required for proper function
- interacts with the cytoplasmic tail of APP & APBB1/FE65 (putative)
- interacts with PLA2G4A/CPLA2, EDNRA & HDAC7
- interacts with TRIM24 & TRIM68
- forms a complex with SENP6 & UBE2I in response to UV irradiation
Structure:
- belongs to the MYST (SAS/MOZ) family
- contains 1 C2HC-type Zn+2 finger
Compartment:
- nucleus, nucleolus, cytoplasm, perinuclear region
- upon stimulation with EDN1, exported from the nucleus to the perinuclear region
- UV irradiation induces translocation into nuclear bodies
Alternative splicing: named isoforms=4
General
acyltransferase
nuclear protein
phosphoprotein
protein subunit
zinc finger protein
Properties
SIZE: entity length = 513 aa
MW = 59 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S86}
Ser phosphorylation site {S90}
Zn finger C2HC-type
SITE: 261-283
EFFECTOR-BOUND: Zn+2
lysine residue {K327}
cysteine residue {C369}
binding site
SITE: 372-372
FOR-BINDING-OF: Acetyl-CoA
Acetyl-CoA binding {377-383}
binding site
SITE: 407-407
FOR-BINDING-OF: Acetyl-CoA
Database Correlations
OMIM 601409
UniProt Q92993
Pfam PF01853
Entrez Gene 10524
Kegg hsa:10524
ENZYME 2.3.1.48
References
- UniProt :accession Q92993
- NIEHS-SNPs
http://egp.gs.washington.edu/data/htatip/
Component-of
NuA4 histone acetyltransferase (HAT) complex