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histone acetylation
Function:
- involved in transcription activation through opening of chromatin by masking positive charge of histone Lys via acetyl groups from Lys & exposing positive charge
- histone acetylation is facilitated by CPA4
- histone deacetylases catalyze histone deacetylation
Pathology:
- histone H4 acetylation is deficient in aged mice; this results in:
a) altered hippocampal chromatin plasticity
b) failure to initiate a hippocampal gene expression program associated with memory consolidation [1]
Related
histone acetylation (GO:0016573)
histone deacetylation
General
acetylation
References
- Peleg S et al
Altered histone acetylation is associated with age-dependent
memory impairment in mice.
Science 2010 May 7; 328:753.
PMID: 20448184