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Histidine triad nucleotide-binding protein 3 (HINT-3, HINT3)
Function:
- hydrolyzes phosphoramidate & acyl-adenylate substrates
- prefers purine over pyrimidine-based substrates
- forms dimers to octamers & even larger oligomer
Kinetic parameters:
- KM=1.5 uM for indolepropinoic acyl-adenylate
- KM=22 uM for adenine
- KM=29 uM for guanine
- KM=32 uM for hypoxanthine
- KM=121 uM for uracil
- KM=181 uM for cytosine
Structure:
- belongs to the HINT family
- contains 1 HIT domain
Compartment:
- cytoplasm, nucleus
- localized as aggregates in the cytoplasm & nucleus
General
hydrolase
Properties
SIZE: entity length = 182 aa
MW = 20 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: HIstidine Triad (HIT domain) {49-160}
MOTIF: Histidine triad motif {143-147}
Database Correlations
UniProt Q9NQE9
Pfam PF01230
Kegg hsa:1351
References
UniProt :accession Q9NQE9