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high-mobility group protein 1-like 2; hepatoma-derived growth factor; HDGF; HMG-1L2 (HDGF, HMG1L2)
Function:
- heparin-binding protein, with mitogenic activity for fibroblasts
- acts as a transcriptional repressor
- sumoylated by SUMO1
- sumoylation prevents binding to chromatin
Structure:
- monomer, & domain-swapped homodimer
- the PWWP domain harbors the heparin-binding sites & is responsible for DNA-binding
- C-terminal region is essentially unstructured
- belongs to the HDGF family
- contains 1 PWWP domain
Compartment: cytoplasm, nucleus
Expression: ubiquitous
General
high-mobility group [HMG] protein
phosphoprotein
Properties
SIZE: entity length = 240 aa
MW = 27 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: PWWP domain {12-69}
MOTIF: binding site
SITE: 19-19
FOR-BINDING-OF: Heparin (Probable)
binding site
SITE: 21-21
FOR-BINDING-OF: Heparin (Probable)
binding site
SITE: 72-72
FOR-BINDING-OF: Heparin (Probable)
peptide motif {75-80}
MOTIF: binding site
SITE: 75-75
FOR-BINDING-OF: Heparin (Probable)
binding site
SITE: 79-79
FOR-BINDING-OF: Heparin (Probable)
binding site
SITE: 80-80
FOR-BINDING-OF: Heparin (Probable)
Ser phosphorylation site {S107}
glutamate-rich region {110-230}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S132}
Ser phosphorylation site {S133}
peptide motif {155-170}
Ser phosphorylation site {S165}
Ser phosphorylation site {S199}
Thr phosphorylation site {T200}
Ser phosphorylation site {S202}
Ser phosphorylation site {S206}
Ser phosphorylation site {S239}
Database Correlations
OMIM 600339
UniProt P51858
Pfam PF00855
Entrez Gene 3068
Kegg hsa:3068
References
UniProt :accession P51858