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non-histone chromosomal protein HMG-17; high-mobility group nucleosome-binding domain-containing protein 2 (HMGN2, HMG17)
Function:
- binds to the inner side of the nucleosomal DNA thus altering the interaction between DNA & the histone octamer
- may have role in maintenance of transcribable genes in an unique chromatin conformation (putative)
- phosphorylation favors cytoplasmic localization
Structure: belongs to the HMGN family
Compartment:
- nucleus, cytoplasm
- cytoplasmic enrichment upon phosphorylation
General
DNA-binding protein
high-mobility group [HMG] protein
phosphoprotein
Properties
SIZE: entity length = 90 aa
MW = 9 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Ser phosphorylation site {S25}
Ser phosphorylation site {S29}
Database Correlations
OMIM 163910
UniProt P05204
Pfam PF01101
Entrez Gene 3151
Kegg hsa:3151
References
- UniProt :accession P05204
- Louie DF
Phosphorylation and subcellular redistribution of high
mobility group proteins 14 and 17, analyzed by mass
spectrometry.
Protein Sci. 2000 Jan;9(1):170-9
PMID: 10739259