high mobility group protein B2; high mobility group protein 2; HMG-2 (HMGB2, HMG2)

Function: - binds preferentially single-stranded DNA - unwinds double stranded DNA - component of the SET complex; within the complex, directly interacts with SET Structure: - belongs to the HMGB family - contains 2 HMG box DNA-binding domains Compartment: nucleus

General

DNA-binding protein high-mobility group [HMG] protein nonhistone chromosomal protein phosphoprotein

Properties

SIZE: entity length = 209 aa MW = 24 kD COMPARTMENT: cell nucleus MOTIF: HMG box SITE: 9-79 MOTIF: Ser phosphorylation site {S35} HMG box SITE: 95-163 MOTIF: Tyr phosphorylation site {Y155} Tyr phosphorylation site {Y162} acidic region {186-209} MOTIF: acidic residue (SEVERAL)

Database Correlations

OMIM 163906 UniProt P26583 Pfam PF00505 Entrez Gene 3148 Kegg hsa:3148

References

UniProt :accession P26583