high mobility group protein 20A (HMG box-containing protein 20A, HMG domain-containing protein HMGX, HMG20A, HMGX1)

Function: 1) role in neuronal differentiation as chromatin-associated protein 2) inhibitor of HMG20B 3) overcomes repressive effects of the neuronal silencer REST & induces activation of neuronal-specific genes 4) role in recruitment of histone methyltransferase MLL & resultant increased methylation of histone H3 lysine 4 Structure: - contains 1 HMG box DNA-binding domain Compartment: nucleus Alternative splicing: named isoforms=2 Expression: ubiquitous

Properties

SIZE: MW = 40 kD entity length = 347 aa COMPARTMENT: cell nucleus MOTIF: HMG box SITE: 103-171 coiled coil {229-273}

Database Correlations

OMIM 605534 UniProt Q9NP66 Pfam PF00505

References

UniProt :accession Q9NP66