high affinity immunoglobulin gamma Fc receptor IB (Fc-gamma RIB, FcRIB, hFcgammaR1B, IgG Fc receptor IB) (FCGR1B IGFRB)

Function: - may bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A - may function in the humoral immune response Structure: - belongs to the immunoglobulin superfamily, FCGR1 family - contains 2 Ig-like C2-type domain (immunoglobulin-like) Compartment: cell membrane Alternative splicing: named isoforms=3 Expression: up-regulated by IFNG

General

Fc gamma receptor glycoprotein

Properties

SIZE: entity length = 280 aa MW = 32 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-15} immunoglobulin superfamily domain {22-101} MOTIF: cysteine residue {C43} MODIFICATION: cysteine residue {C85} N-glycosylation site {N59} cysteine residue {C85} MODIFICATION: cysteine residue {C43} immunoglobulin superfamily domain {95-184} MOTIF: cysteine residue {C124} MODIFICATION: cysteine residue {C168} N-glycosylation site {N152} N-glycosylation site {N163} cysteine residue {C168} MODIFICATION: cysteine residue {C124} transmembrane domain {199-219}

Database Correlations

OMIM 601502 UniProt Q92637 Pfam PF00047 Kegg hsa:2210

References

UniProt :accession Q92637