high affinity immunoglobulin alpha & immunoglobulin mu Fc receptor (Fc alpha/mu receptor, FCAMR)

Function: - receptor for the Fc fragment of IgA & IgM - binds IgA & IgM with high affinity & mediates their endocytosis - may function in the immune response to microbes mediated by IgA & IgM Structure: - N-glycosylated - contains 1 Ig-like V-type domain (immunoglobulin-like) Compartment: cell membrane Alternative splicing: named isoforms=4 Expression: - expressed by mesangial cells - up-regulated by IFNG in mesangial cells

General

Fc receptor glycoprotein

Properties

SIZE: entity length = 532 aa MW = 57 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-16} immunoglobulin superfamily domain {61-169} MOTIF: Mediates immunoglobulin Fc fragment-binding {75-97} cysteine residue {C82} MODIFICATION: cysteine residue {C153} cysteine residue {C153} MODIFICATION: cysteine residue {C82} N-glycosylation site {N167} transmembrane domain {451-471}

Database Correlations

OMIM 605484 UniProt Q8WWV6 Pfam PF07686 Kegg hsa:8395

References

UniProt :accession Q8WWV6