hexokinase

Function: - carbohydrate metabolism, hexose metabolism - allosteric enzyme inhibited by its product Glc-6-P ATP + D-hexose ADP + D-hexose 6-phosphate Structure: - monomer - N- & C-terminal halves show extensive sequence similarity to each other - catalytic activity is associated with the C-terminus - regulatory function is associated with the N-terminus hydrophobic N-terminal sequence may be involved in membrane binding Laboratory: - hexokinase in erythrocytes Notes: - in vertebrates there are 4 major glucose-phosphorylating isoenzymes, designated: - hexokinase 1 - hexokinase 2 - hexokinase 3 - hexokinase 4 (glucokinase)

Related

glycolytic pathway (glycolysis, Embden Myerhof pathway) hexokinase in erythrocytes

Specific

glucokinase, hexokinase-D or hexokinase-4 hexokinase HKDC1 (hexokinase domain-containing protein 1, HKDC1) Hexokinase-1 (hexokinase type I, HK I, brain form hexokinase, HK1) hexokinase-2 (hexokinase type II, HK II, muscle form hexokinase, HK2) hexokinase-3 (hexokinase type III, HK III, HK3)

General

glycolytic enzyme kinase or ATP-phosphotransferase

Properties

COMPARTMENT: cytoplasm MOTIF: active site

References

- Wikipedia; hexokinase entry http://en.wikipedia.org/wiki/hexokinase