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obestatin (hexarelin)

Function: - may be the ligand for GPR39 - may have an appetite-reducing effect resulting in decreased food intake - may reduce gastric emptying activity & jejunal motility - effects are not synergistic with ghrelin Structure: - amidation of Leu-98 is essential for obestatin activity Expression: - derived from same precursor, appetite regulating hormone, as ghrelin - effects are probably synergistic with GHRH

Related

ghrelin; ghrelin -27; ghrelin-28

General

secreted peptide

Properties

COMPARTMENT: extracellular compartment

References

  1. UniProt :accession Q9UBU3
  2. Solomon DH, in: UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001