heterogeneous nuclear ribonucleoprotein U; hnRNP U; scaffold attachment factor A; SAF-A; p120; pp120 (HNRNPU, HNRPU, SAFA, U211)

Function: - binds to pre-mRNA - has high affinity for scaffold-attached region (SAR) DNA - binds to double-stranded DNA & single-stranded DNA & RNA - extensively phosphorylated - Arg-733 & Arg-739 are dimethylated, probably to asymmetric dimethylarginine - identified in the spliceosome C complex - ligand for CR2 Structure: - contains 1 B30.2/SPRY domain - contains 1 SAP domain Compartment: - nucleus, cell surface - component of ribonucleosomes - also found associated with the cell surface Alternative splicing: named isoforms=2; long, short

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 825 aa MW = 91 kD COMPARTMENT: cell nucleus MOTIF: acidic region {2-160} MOTIF: acidic residue (SEVERAL) acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S4} SAP {8-42} MOTIF: Ser phosphorylation site {S26} Ser phosphorylation site {S59} Ser phosphorylation site {S66} glutamate-rich region {84-94} MOTIF: glutamate residue (SEVERAL) glutamine-rich region {161-209} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S188} B30.2/SPRY {267-464} MOTIF: Ser phosphorylation site {S271} Tyr phosphorylation site {Y473} ATP-binding site NAME: ATP-binding site SITE: 504-511 glycine-rich region {703-825} MOTIF: binding site SITE: 714-739 FOR-BINDING-OF: ribonucleic acid glycine-rich region {740-750}

Database Correlations

OMIM 602869 UniProt Q00839 PFAM correlations Entrez Gene 3192 Kegg hsa:3192

References

UniProt :accession Q00839