heterogeneous nuclear ribonucleoprotein A3; hnRNP A3 (HNRNPA3, HNRPA3)

Function: - plays a role in cytoplasmic trafficking of RNA - binds to the cis-acting response element, A2RE - may be involved in pre-mRNA splicing - identified in the spliceosome C complex Structure: - contains 2 RRM domain (RNA recognition motif)s Compartment: - nucleus (putative) - component of ribonucleosomes Alternative splicing: named isoforms=2

General

heterogeneous nuclear ribonucleoprotein (hnRNP) phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 378 aa MW = 40 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S14} RNP motif NAME: RNP motif SITE: 35-118 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S116} RNP motif NAME: RNP motif SITE: 126-205 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif glycine-rich region {211-378} MOTIF: Ser phosphorylation site {S355} Ser phosphorylation site {S356} Ser phosphorylation site {S358} Tyr phosphorylation site {Y360} Tyr phosphorylation site {Y364} Ser phosphorylation site {S366} Ser phosphorylation site {S370} Ser phosphorylation site {S375}

Database Correlations

OMIM 605372 UniProt P51991 Pfam PF00076 Entrez Gene 220988 Kegg hsa:220988

References

UniProt :accession P51991