chromobox protein homolog 3; heterochromatin protein 1 homolog gamma; HP1 gamma; modifier 2 protein; HECH (CBX3)

Function: - component of heterochromatin - seems to be involved in transcriptional silencing in heterochromatin-like complexes - recognizes & binds histone H3 tails methylated at Lys-9, leading to epigenetic repression - may contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor - role in formation of functional kinetochore through interaction with MIS12 complex proteins - phosphorylated by PIM1 - phosphorylated during interphase - possibly hyper-phosphorylated during mitosis - binds directly to CHAF1A - interacts with histone H3 methylated at Lys-9 - part of the E2F6.com-1 complex - interacts with LBR, INCENP, TRIM28/TIF1B, SUV420H1, SUV420H2 & SP100 - interacts with TIF1A (putative) - interacts with MIS12 & DSN1 - can interact directly with CBX5 via the chromoshadow domain Structure: contains 2 chromo domains Compartment: - nucleus (putative) - associates with euchromatin & is largely excluded from constitutive heterochromatin - may be associated with microtubules & mitotic poles during mitosis (putative)

Properties

SIZE: entity length = 183 aa MW = 21 kD COMPARTMENT: cell nucleus MOTIF: chromodomain NAME: chromodomain SITE: 30-88 FOR-BINDING-OF: heterochromatin Ser phosphorylation site {S93} Ser phosphorylation site {S95} Ser phosphorylation site {S97} chromodomain NAME: chromodomain SITE: 121-179 FOR-BINDING-OF: heterochromatin MOTIF: Ser phosphorylation site {S176}

Database Correlations

OMIM 604477 UniProt Q13185 PFAM correlations Entrez Gene 11335 Kegg hsa:11335

References

UniProt :accession Q13185