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chromobox protein homolog 1; heterochromatin protein 1 homolog beta; HP1 beta; modifier 1 protein; M31; heterochromatin protein p25; HP1Hsbeta; p25beta (CBX1 CBX)
Function:
- component of heterochromatin
- recognizes & binds histone H3 tails methylated at Lys-9, leading to epigenetic repression
- interaction with lamin B receptor (LBR) may contribute to association of heterochromatin with the inner nuclear membrane
- not phosphorylated
- interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A & TRIM28/TIF1B PXVXL motif via the chromoshadow domain
- interacts directly with histone H3 methylated at Lys-9 via the chromo domain
- interacts with SUV39H1 & SETDB1, SUV420H1 & SUV420H2
- interacts with PRDM6
Structure:
- homodimer
- contains 2 chromo domains
Compartment:
- nucleus
- not associated with chromosomes during mitosis
Expression: In all adult & embryonic tissues
General
heterochromatin protein 1 homolog
Properties
SIZE: entity length = 185 aa
MW = 21 kD
COMPARTMENT: cell nucleus
MOTIF: chromodomain
NAME: chromodomain
SITE: 21-79
FOR-BINDING-OF: heterochromatin
MOTIF: binding site
SITE: 21-21
FOR-BINDING-OF: Histone H3-K9Me2
binding site
SITE: 23-23
FOR-BINDING-OF: Histone H3-A7
binding site
SITE: 40-40
FOR-BINDING-OF: Histone H3-A7
binding site
SITE: 42-42
FOR-BINDING-OF: Histone H3-A7
binding site
SITE: 42-42
FOR-BINDING-OF: Histone H3-K9Me2
binding site
SITE: 45-45
FOR-BINDING-OF: Histone H3-K9Me2
binding site
SITE: 58-58
FOR-BINDING-OF: Histone H3-A7
binding site
SITE: 60-60
FOR-BINDING-OF: Histone H3-A7
Ser phosphorylation site {S89}
chromodomain
NAME: chromodomain
SITE: 117-175
FOR-BINDING-OF: heterochromatin
MOTIF: binding site
SITE: 125-125
FOR-BINDING-OF: PxVxL motif
binding site
SITE: 126-126
FOR-BINDING-OF: PxVxL motif
binding site
SITE: 135-135
FOR-BINDING-OF: PxVxL motif
binding site
SITE: 146-146
FOR-BINDING-OF: PxVxL motif
binding site
SITE: 163-163
FOR-BINDING-OF: PxVxL motif
binding site
SITE: 167-167
FOR-BINDING-OF: PxVxL motif
binding site
SITE: 168-168
FOR-BINDING-OF: PxVxL motif
binding site
SITE: 170-170
FOR-BINDING-OF: PxVxL motif
Ser phosphorylation site {S175}
Database Correlations
OMIM 604511
UniProt P83916
PFAM correlations
Entrez Gene 10951
Kegg hsa:10951
References
- UniProt :accession P83916
- Wikipedia; Note: heterochromatin protein 1 entry
http://en.wikipedia.org/wiki/heterochromatin_protein_1