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heterochromatin protein 1-binding protein 3 (protein HP1-BP74, HP1BP3)
Function:
- component of heterochromatin
- may be involved in chromatin structure & function
- interacts with CBX5 (putative)
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure:
- in the C-terminal section; belongs to the histone H1/H5 family
Compartment: nucleus (putative)
Alternative splicing: named isoforms=5
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 553 aa
MW = 61 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S6}
Thr phosphorylation site {T132}
Ser phosphorylation site {S142}
Ser phosphorylation site {S156}
Ser phosphorylation site {S431}
Ser phosphorylation site {S441}
Ser phosphorylation site {S442}
Ser phosphorylation site {S446}
lysine-rich region {454-553}
MOTIF: lysine residue (SEVERAL)
Database Correlations
UniProt Q5SSJ5
Pfam PF00538
Kegg hsa:5080
References
UniProt :accession Q5SSJ5