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HERV-FRD 6p24.1 provirus ancestral Env polyprotein; HERV-FRD; Syncytin-2 [Contains: Surface protein (SU); Transmembrane protein (TM)] (ERVFRDE1, ERVFRD-1)
Also see endogenous retroviral envelope polyprotein
Function:
1) has retained its original fusogenic properties
2) can make pseudotypes with MLV, HIV-1 or SIV-1 virions & confer infectivity
Expression:
- expressed in placenta > adrenal, bone marrow, brain, breast, colon, kidney, lung, ovary, peripheral blood lymphocytes, prostate, skin, spleen, testis, thymus, thyroid, trachea Comarative biology:
- ortholog in old-world & new-world monkeys, but not in prosimians
Genetics: HERV-FRD subgenomic RNA has been observed
General
endogenous retroviral envelope polyprotein
glycoprotein
Properties
SIZE: MW = 60 kD
entity length = 538 aa
MOTIF: signal sequence {1-15}
CXXC {43-46}
N-glycosylation site {N133}
N-glycosylation site {N146}
N-glycosylation site {N177}
N-glycosylation site {N220}
N-glycosylation site {N241}
N-glycosylation site {N247}
N-glycosylation site {N312}
N-glycosylation site {N332}
proteolytic site {350-351}
Fusion peptide {354-374}
CKS-17 {414-430}
CX6CC {431-439}
MOTIF: cysteine residue {C431}
MODIFICATION: cysteine residue {C438}
cysteine residue {C438}
MODIFICATION: cysteine residue {C431}
N-glycosylation site {N443}
transmembrane domain {479-499}
Database Correlations
UniProt P60508
Pfam PF00429
References
- UniProt :accession P60508
- Human Endogenous Retrovirus Database (HERVd)
http://herv.img.cas.cz/cgi-bin/draw_full_element.cgi?fid=125345