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her2/neu proto-oncogene (erb-B2)
Overexpression in 25% of cases of breast cancer. Overexpression predicts more aggressive disease.
Related
HER2 copy number
receptor tyrosine-protein kinase erbB-2; p185erbB2; C-erbB-2; NEU proto-oncogene; tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 (ERBB2, HER2, NEU, NGL)
General
erb proto-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: erbB2 receptor
LOCUS: human chromosome-17 Q21-22
MOTIF: transcription factor binding site
transcriptional start site
exon
intron
transcriptional termination site
transcriptional termination site
Database Correlations
OMIM 164870
MORBIDMAP 164870
References
- Cantley LC, Auger KR, Carpenter C, Duckworth B,
Graziani A, Kapeller R, Soltoff S.
Oncogenes and signal transduction.
Cell. 1991 Jan 25;64(2):281-302. Review.
Erratum in: Cell 1991 May 31;65(5):following 914.
PMID: 1846320
- OMIM :accession 256550